Central diabetes insipidus unmasked by kidney transplantation: a case report and literature review

Central diabetes insipidus unmasked by kidney transplantation: a case report and literature review

Blog Article

Background: Diabetes insipidus (DI) is a relatively uncommon abnormality of water homeostasis resulting in the excess production of hypotonic polyuria.Post-transplant polyuria is typically self-limited and resolves without intervention.We present a case of severe and persistent post-transplant polyuria secondary to previously undiagnosed central DI.Methods: A case of persistent polyuria following kidney transplant is presented, demonstrating the diagnosis and management of central DI following kidney transplant.

A literature review of central DI after kidney transplant was performed to provide context of this Chafer Fuel extremely rare condition.Results: A 59-year-old female with chronic kidney disease received a pediatric en bloc kidney transplant, and exhibited massive polyuria for five days following transplant.Desmopressin therapy resulted in resolution of the polyuria, but labile sodium levels resulted in the development of a seizure.Imaging demonstrated an empty sella supporting the diagnosis of central DI.

A total of five prior case reports ART of DI after kidney transplantation, the majority which were diagnosed prior to kidney transplant, and typically in patients with prior intracranial surgery.Conclusion: While early polyuria is frequent following kidney transplant, persistent massive polyuria requires further workup, and DI should be considered.